Pre-experiment growth in carboys.jpg

Algal Biotechnology

We develop and apply novel technologies to industrial needs using a variety of algal strains and algal-bacterial consortia.

 

We use synthetic biology tools to increase carotenoid productivity in Chlamydomonas reinhardtii, chemical inhibitors and adaptive evolution with Nannochloropsis oculata for generating long chain, polyunsaturated fatty acids, and also work closely with ecologists to decipher the mechanisms of natural info-chemicals and how these can be used to reduce costs/environmental impacts of downstream processing when using Scenedesmus subspicatus.

More recently we have generated a suite of tuneable promoters for recombinant protein expression in C. reinhardtii.

Gallery

Culture Oil Extractions - Sodium Sulfate Drying
Culture Oil Extractions - Sodium Sulfate Drying
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E6QvVWcXsAcTw9Q
E6QvVWcXsAcTw9Q
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IMG_20201023_095059
IMG_20201023_095059
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Freeze-dried biomass samples
Freeze-dried biomass samples
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IMG_20210205_083322
IMG_20210205_083322
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Picture 3
Picture 3
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Picture 4
Picture 4
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nella floc.jpg
nella floc.jpg
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Bioreactor with algae.jpg
Bioreactor with algae.jpg
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algae flasks.jpg
algae flasks.jpg
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Phycoflow inoculated 2.JPG
Phycoflow inoculated 2.JPG
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Carbuoy.jpg
Carbuoy.jpg
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Selected Published Work

Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model

2021

  • Danielle J Smyth, Bijie Ren, Madeleine P J, White, Caitlin McManus, Holly Webster, Vivien Shek, Caroline Evans, Jagroop Pandhal, Francis Fields, Rick M Maizels, Stephen Mayfield. J Biotechnol.

The Effect of High-Intensity Ultraviolet Light to Elicit Microalgal Cell Lysis and Enhance Lipid Extraction

2018

  • Thomas Sydney, Jo-Ann Marshall-Thompson, Rahul Vijay Kapoore, Seetharaman Vaidyanathan, Jagroop Pandhal, J Patrick A Fairclough. Metabolites 8(4):65

Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery.

2018

  • Kapoore RV, Butler TO, Pandhal J, Vaidyanathan S. (2018) Biology, (7):1

Quantitative proteomics reveals reduction in photosynthetic capacity of a B12-dependent alga grown in mutualistic coculture with bacteria

2018

  • Helliwell KE, Pandhal J, Cooper MB, Longworth J, Kudahl UJ, Russo D, Tomsett EV, Bunbury F, Salmon D, Wright PC, Smirnoff N, Smith AG (2018) New Phytologist 217(2):599-612.

Competitive growth experiments with a high-lipid Chlamydomonas reinhardtii mutant strain and its wild-type to predict industrial and ecological risks

2017

  • Russo D, Beckerman AP, Pandhal J, (2017) AMB Express 7(10).

The use of natural infochemicals for sustainable and efficient harvesting of microalgae for biotechnology: insights from a meta-analysis

2016

  • Roccuzzo S, Beckerman A, Pandhal J, (2016) Biotech Letters 38(12):1983-1990.

Synthetic microbial ecosystems for biotechnology

2014

  • Pandhal J., Noirel, J. (2014) Biotechnology Letters 36(6):1141-51

Get in Touch

Selected Published Work

Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model

2021

  • Danielle J Smyth, Bijie Ren, Madeleine P J, White, Caitlin McManus, Holly Webster, Vivien Shek, Caroline Evans, Jagroop Pandhal, Francis Fields, Rick M Maizels, Stephen Mayfield. J Biotechnol.

Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery.

2018

  • Kapoore RV, Butler TO, Pandhal J, Vaidyanathan S. (2018) Biology, (7):1

Quantitative proteomics reveals reduction in photosynthetic capacity of a B12-dependent alga grown in mutualistic coculture with bacteria

2018

  • Helliwell KE, Pandhal J, Cooper MB, Longworth J, Kudahl UJ, Russo D, Tomsett EV, Bunbury F, Salmon D, Wright PC, Smirnoff N, Smith AG (2018) New Phytologist 217(2):599-612.

Competitive growth experiments with a high-lipid Chlamydomonas reinhardtii mutant strain and its wild-type to predict industrial and ecological risks

2017

  • Russo D, Beckerman AP, Pandhal J, (2017) AMB Express 7(10).

The use of natural infochemicals for sustainable and efficient harvesting of microalgae for biotechnology: insights from a meta-analysis

2016

  • Roccuzzo S, Beckerman A, Pandhal J, (2016) Biotech Letters 38(12):1983-1990.

Synthetic microbial ecosystems for biotechnology

2014

  • Pandhal J., Noirel, J. (2014) Biotechnology Letters 36(6):1141-51

Get in Touch