Algal Biotechnology
We develop and apply novel technologies to industrial needs using a variety of algal strains and algal-bacterial consortia.
We use synthetic biology tools to increase carotenoid productivity in Chlamydomonas reinhardtii, chemical inhibitors and adaptive evolution with Nannochloropsis oculata for generating long chain, polyunsaturated fatty acids, and also work closely with ecologists to decipher the mechanisms of natural info-chemicals and how these can be used to reduce costs/environmental impacts of downstream processing when using Scenedesmus subspicatus.
More recently we have generated a suite of tuneable promoters for recombinant protein expression in C. reinhardtii.
Gallery
Selected Published Work
Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model
2021
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Danielle J Smyth, Bijie Ren, Madeleine P J, White, Caitlin McManus, Holly Webster, Vivien Shek, Caroline Evans, Jagroop Pandhal, Francis Fields, Rick M Maizels, Stephen Mayfield. J Biotechnol.
The Effect of High-Intensity Ultraviolet Light to Elicit Microalgal Cell Lysis and Enhance Lipid Extraction
2018
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Thomas Sydney, Jo-Ann Marshall-Thompson, Rahul Vijay Kapoore, Seetharaman Vaidyanathan, Jagroop Pandhal, J Patrick A Fairclough. Metabolites 8(4):65
Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery.
2018
Kapoore RV, Butler TO, Pandhal J, Vaidyanathan S. (2018) Biology, (7):1
Quantitative proteomics reveals reduction in photosynthetic capacity of a B12-dependent alga grown in mutualistic coculture with bacteria
2018
Helliwell KE, Pandhal J, Cooper MB, Longworth J, Kudahl UJ, Russo D, Tomsett EV, Bunbury F, Salmon D, Wright PC, Smirnoff N, Smith AG (2018) New Phytologist 217(2):599-612.
Competitive growth experiments with a high-lipid Chlamydomonas reinhardtii mutant strain and its wild-type to predict industrial and ecological risks
2017
Russo D, Beckerman AP, Pandhal J, (2017) AMB Express 7(10).
The use of natural infochemicals for sustainable and efficient harvesting of microalgae for biotechnology: insights from a meta-analysis
2016
Roccuzzo S, Beckerman A, Pandhal J, (2016) Biotech Letters 38(12):1983-1990.
Synthetic microbial ecosystems for biotechnology
2014
Pandhal J., Noirel, J. (2014) Biotechnology Letters 36(6):1141-51
Selected Published Work
Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model
2021
-
Danielle J Smyth, Bijie Ren, Madeleine P J, White, Caitlin McManus, Holly Webster, Vivien Shek, Caroline Evans, Jagroop Pandhal, Francis Fields, Rick M Maizels, Stephen Mayfield. J Biotechnol.
Microwave-Assisted Extraction for Microalgae: From Biofuels to Biorefinery.
2018
Kapoore RV, Butler TO, Pandhal J, Vaidyanathan S. (2018) Biology, (7):1
Quantitative proteomics reveals reduction in photosynthetic capacity of a B12-dependent alga grown in mutualistic coculture with bacteria
2018
Helliwell KE, Pandhal J, Cooper MB, Longworth J, Kudahl UJ, Russo D, Tomsett EV, Bunbury F, Salmon D, Wright PC, Smirnoff N, Smith AG (2018) New Phytologist 217(2):599-612.
Competitive growth experiments with a high-lipid Chlamydomonas reinhardtii mutant strain and its wild-type to predict industrial and ecological risks
2017
Russo D, Beckerman AP, Pandhal J, (2017) AMB Express 7(10).
The use of natural infochemicals for sustainable and efficient harvesting of microalgae for biotechnology: insights from a meta-analysis
2016
Roccuzzo S, Beckerman A, Pandhal J, (2016) Biotech Letters 38(12):1983-1990.
Synthetic microbial ecosystems for biotechnology
2014
Pandhal J., Noirel, J. (2014) Biotechnology Letters 36(6):1141-51